Utilizing Intact Cardiac Cell Electrophysiological Protocols to Create more Robust Computational Models
The traditional paradigm for developing cardiac computational cell models utilizes data from multiple cell types, species, laboratories, and experimental conditions to create a composite model. While such models can accurately represent data in limited biological scenarios, their ability to predict behavior outside of a narrow dynamic window is limited. This talk will describe novel electrophysiological protocols that aim to densely sample the dynamics of intact cardiac myocytes. The information-rich data from such protocols are then fit using complex parameter optimization algorithms to tune multiple model parameters at one time. By so doing, this approach yields cell models that fit wide-ranging cellular behavior, making them better suited to make physiological and pathophysiological predictions.
David Christini received a BS degree in electrical engineering from the Pennsylvania State University and MS and PhD degrees in biomedical engineering from Boston University. He is a Professor in the Departments of Medicine and Physiology and Biophysics, Weill Cornell Medical College, New York. His group’s efforts are focused on improving the understanding of, and therapies for, cardiac arrhythmias. Their experiments employ electrophysiological and imaging modalities, primarily at the cellular and tissue levels. They combine experimental data with clinical data to inform computational cardiac modeling that scales up from the single cell to the whole organ. Such a combination of experimental, computational, and clinical approaches provides the synergy to impact understanding of cardiac arrhythmias.